Scientists discover protein that could heal leaky gut and ease depression

Chronic stress can damage the gut’s protective lining, triggering inflammation that may worsen depression. New research shows that stress lowers levels of a protein called Reelin, which plays a key role in both gut repair and brain health. Remarkably, a single injection restored Reelin levels and produced antidepressant-like effects in preclinical models. The findings hint at a future treatment that targets depression through the gut–brain connection.